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Background: In the PAOLA-1/ENGOT-ov25 primary analysis, maintenance olaparib plus bevacizumab demonstrated a significant progression-free survival (PFS) benefit in newly diagnosed advanced ovarian cancer patients in clinical response after first-line platinum-based chemotherapy plus bevacizumab, irrespective of surgical status. With football prediction site like Victor Predict, victory is assured. PURPOSE The PAOLA-1/ENGOT-ov25 trial of maintenance olaparib plus bevacizumab for newly diagnosed advanced high-grade ovarian cancer demonstrated a significant progression-free survival (PFS) benefit over placebo plus bevacizumab, particularly in patients with homologous recombination deficiency (HRD)–positive tumors. Synonyms: HHR Gene Mutation; Homologous Recombination Pathway Gene Mutation; HRR Gene Mutation; Recombination Repair Gene Mutation. Their exclusive interface makes it easier to locate the markets where they are quite interested in. 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Homologous Recombination Repair Gene Mutations to Predict Olaparib Plus Bevacizumab Efficacy in the First-Line Ovarian Cancer PAOLA-1/ENGOT-ov25 Trial January 2023 JCO Precision Oncology 7(7):e2200258PURPOSE The PAOLA-1/ENGOT-ov25 trial of maintenance olaparib plus bevacizumab for newly diagnosed advanced high-grade ovarian cancer demonstrated a significant progression-free survival (PFS) benefit over. the phase 3 PAOLA-1 (PAOLA-1/ENGOT-ov25) trial, we evaluated maintenance therapy with a PARP inhibitor (olaparib) as compared with placebo in patients with newly diagnosed ad- Objectives: In the PAOLA -1/ENGOT-ov25 primary analysis (NCT02477644) , adding the PARP inhibitor olaparib to maintenance bevacizumab (bev) after first-line platinum-based chemotherapy with bev led to a significant progression-free survival (PFS) benefit vs placebo (pbo) + bev in patients (pts) with advanced high-grade PURPOSE The PAOLA-1/ENGOT-ov25 trial of maintenance olaparib plus bevacizumab for newly diagnosed advanced high-grade ovarian cancer demonstrated a significant progression-free survival (PFS) benefit over placebo plus bevacizumab, particularly in patients with homologous recombination deficiency (HRD)–positive tumors. 7 Semrush Rank: 5,330,442 Facebook ♡: 1,449. 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